Classes Dermatological/Topical Agent
Topical Antiinfective Agent
Antiacne Agent
Diseases Acne
Skin Disorder


Adapalene is a retinoid. Adapalene binds to specific retinoic acid nuclear receptors but does not bind to cytosolic receptor protein.  Biochemical and pharmacological profile studies have demonstrated that adapalene is a modulator of cellular differentiation, keratinization, and inflammatory processes. However, the significance of these findings with regard to the mechanism of action of adapalene for the treatment of acne is unknown. 


Adapalene is indicated for the topical treatment of acne vulgaris in patients 12 years of age and older. 


  • Apply a thin film of Adapalene Gel, 0.3% to the entire face and any other affected areas of the skin once daily in the evening, after washing gently with a non-medicated soap.
  • For topical use only.
  • Not for ophthalmic, oral or intravaginal use.


The most frequently reported adverse reactions were-

  • dry skin
  • skin discomfort
  • pruritus
  • desquamation
  • sunburn


Ultraviolet Light and Environmental Exposure:  

  • Avoid exposure to direct sunlight and sunlamps.
  • Wear sunscreen when sun exposure cannot be avoided.
  • Erythema, scaling, dryness, and stinging/burning were reported with use of Adapalene Gel.



Adapalene should not be administered to individuals who are hypersensitive to adapalene or any of the components in the gel vehicle.